The two mutations, Q204X and nt821, of the myostatin gene affect carcass and meat quality in young heterozygous bulls of French beef breeds1 (2024)

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Volume 88 Issue 2 February 2013
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S. Allais

*INRA, UMR 1313 Unité de Génétique Animale et Biologie Intégrative, F-78350 Jouy en Josas, France

Union Nationale des Coopératives agricoles d'Elevage et d'Insémination Animale, F-75595 Paris Cedex 12, France

2Corresponding author: sophie.allais@jouy.inra.fr

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H. Levéziel

INRA, UMR 1061 Unité de Génétique Moléculaire Animale, F-87060 Limoges, France

§Université de Limoges, UMR 1061 Unité de Génétique Moléculaire Animale, F-87060 Limoges, France

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N. Payet-Duprat

INRA, UMR 1061 Unité de Génétique Moléculaire Animale, F-87060 Limoges, France

§Université de Limoges, UMR 1061 Unité de Génétique Moléculaire Animale, F-87060 Limoges, France

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J. F. Hocquette

#INRA, UR 1213 Unité de Recherche sur les Herbivores, F-63122 Saint Genès Champanelle, France

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J. Lepetit

INRA, UR 370 Unité Qualité des Produits Animaux, F-63122 Saint Genès Champanelle, France

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S. Rousset

INRA, UMR 1019 Unité de Nutrition Humaine, Centre de Recherches en Nutrition Humaine d'Auvergne, F-63001 Clermont-Ferrand, France

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C. Denoyelle

**Institut de l'Elevage, F-75595 Paris Cedex 12, France

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C. Bernard-Capel

**Institut de l'Elevage, F-75595 Paris Cedex 12, France

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L. Journaux

Union Nationale des Coopératives agricoles d'Elevage et d'Insémination Animale, F-75595 Paris Cedex 12, France

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A. Bonnot

**Institut de l'Elevage, F-75595 Paris Cedex 12, France

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G. Renand

*INRA, UMR 1313 Unité de Génétique Animale et Biologie Intégrative, F-78350 Jouy en Josas, France

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Journal of Animal Science, Volume 88, Issue 2, February 2013, Pages 446–454, https://doi.org/10.2527/jas.2009-2385

Published:

01 February 2010

Article history

Received:

10 August 2009

Accepted:

29 October 2009

Published:

01 February 2010

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    S. Allais, H. Levéziel, N. Payet-Duprat, J. F. Hocquette, J. Lepetit, S. Rousset, C. Denoyelle, C. Bernard-Capel, L. Journaux, A. Bonnot, G. Renand, The two mutations, Q204X and nt821, of the myostatin gene affect carcass and meat quality in young heterozygous bulls of French beef breeds, Journal of Animal Science, Volume 88, Issue 2, February 2013, Pages 446–454, https://doi.org/10.2527/jas.2009-2385

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ABSTRACT

The availability of genetic tests to detect different mutations in the myostatin gene allows the identification of heterozygous animals and would warrant the superiority of these animals for slaughter performance if this superiority is confirmed. Thus, 2 mutations of this gene, Q204X and nt821, were studied in 3 French beef breeds in the program Qualvigène. This work was done with 1,114 Charolais, 1,254 Limousin, and 981 Blonde d'Aquitaine young bulls from, respectively, 48, 36, and 30 sires and slaughtered from 2004 to 2006. In addition to the usual carcass traits recorded at slaughter (e.g., carcass yield, muscle score), carcass composition was estimated by weighing internal fat and dissecting the 6th rib. The muscle characteristic traits analyzed were lipid and collagen contents, muscle fiber section area, and pH. Regarding meat quality, sensory qualities of meat samples were evaluated by a taste panel, and Warner-Bratzler shear force was measured. Deoxyribonucleic acid was extracted from the blood samples of all calves, the blood samples of 78% of the dams, and the blood or sem*n samples of all the sires. Genotypes were determined for 2 disruptive mutations, Q204X and nt821. Analyses were conducted by breed. The superiority of carcass traits of calves carrying one copy of the mutated allele (Q204X or nt821) over noncarrier animals was approximately +1 SD in the Charolais and Limousin breeds but was not significant in the Blonde d'Aquitaine. In the Charolais breed, for which the frequency was the greatest (7%), young bulls carrying the Q204X mutation presented a carcass with less fat, less intramuscular fat and collagen contents, and a clearer and more tender meat than those of hom*ozygous-normal cattle. The meat of these animals also had slightly less flavor. Also in the Charolais breed, 13 of 48 sires were heterozygous. For each sire, the substitution effect of the wild allele by the mutant allele was approximately +1 SD for carcass conformation and yield, showing that the estimate of the substitution effect was independent of family structure, as it ought to be for a causal mutation. These results illustrate the challenge of using genetic tests to detect animals with the genetic potential for greater grades of carcasses and meat quality.

© American Society of Animal Science 2010

Issue Section:

Animal Genetics > Molecular Genetics

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